Great Brington is a village in the Daventry district of the county of Northamptonshire, England. The village, in the civil parish of Brington, has a population of about 200. The parish church of Great Brington is dedicated to St Mary the Virgin and St John.
In 1508, John Spencer from Wormleighton in Warwickshire purchased the estate of Althorp outside Great Brington with its moated house and several hundred acres of farmland. He had grazed sheep here from the 1480s. In 1508, impressed by the quality of the land, he eventually bought it and rebuilt the house. In 1511 he made further purchases to acquire much of the surrounding countryside, including the villages of Little Brington and Great Brington as well their parish church of St Mary the Virgin, from Thomas Grey, 2nd Marquess of Dorset.
Just outside the village is Althorp, the home of the Spencer family and Diana, Princess of Wales. Several members of the Spencer family are buried at Great Brington church, including Diana's father the 8th Earl Spencer, who died in 1992. The death of Diana had quite an effect on the village - the village pub was renamed from "The Fox and Hounds" to the "Althorp Coaching Inn" and the previously sleepy post office gained currency exchange facilities following the large increase in tourism to the area.