Great Barford is a village and civil parish in Bedfordshire, England, a few miles north-east of Bedford. It lies on the River Great Ouse at . It is twinned with Wöllstein, Germany. The village is bypassed by the busy A421 road on the way between Bedford and St Neots in Cambridgeshire, the bypass opening on 24 August 2006.
The village is known for its All Saints Church, with a 15th-century tower, and its similarly ancient bridge . The surroundings and historic buildings make it a favoured destination for canoeing, angling and picnics. Nearby places include Renhold and Blunham.