Deniliquin is located at the intersection of the Riverina and Cobb Highway approximately south west of the state capital, Sydney and north of Melbourne. The town is divided in two parts by the Edward River, an anabranch of the Murray River, with the main business district located on the south bank.
The town services a productive agricultural district with prominent rice, wool and timber industries. At the 2006 census, Deniliquin had a population of 7,431. In the 2001 census the population of Deniliquin was 7,781.