Coxsackie is a town in Greene County, New York, United States. The population was 8,918 at the 2010 census. The name of the town is said to be derived from a Native American term, but it has various translations ("owl's hoot" is locally common).
The town of Coxsackie is notable for being the namesake of Coxsackievirus since it was first discovered here.
The settlement of Coxsackie began in the 17th Century, around 1652 as part of the development of New Netherlands. The area became a district in 1772, and the Town of Coxsackie was founded in 1788. Part of Coxsackie was lost when the Town of Durham was formed in 1790. Further land was lost in the formation of the newer Towns of Cairo and Greenville, Greene County, New York (1803), New Baltimore (1811), and Athens in 1815.
One of the first settlers here was Pieter Bronck, of the same family for which The Bronx is named. In 1663, he built the Pieter Bronck House in West Coxsackie (open as a museum). The nearby family burial ground includes a separate plot with marked graves for slaves of the family.
In 1900, the combined population of the town and village was 2,994.