The Regional District of Comox-Strathcona was a regional district of British Columbia, Canada from 1967 to 2008. On February 15, 2008, the regional district was abolished and replaced by two successor regional districts, Comox Valley and Strathcona.
The district covered large portions of northern Vancouver Island and included part of the mainland north of the Sunshine Coast. As of the 2006 Census, the Regional District had a population of 101,595. The district's administrative offices were located in Courtenay, although the most populous incorporated community was the District Municipality of Campbell River.