The Clarksdale Micropolitan Statistical Area includes all of Coahoma County.
Coahoma County was established February 9, 1836, and is located in the northwestern part of the state in the fertile Yazoo Delta region. The name "Coahoma" is a Choctaw word meaning "red panther." The act creating the county defined its limits as follows:
Beginning at the point where the line between townships 24 and 25 of the surveys of the late Choctaw cession intersects the Mississippi River, and running thence up the said river to the point where the dividing line between the Choctaw and Chickasaw tribes of Indians intersects the same; thence with the dividing line to the point where the line between ranges two and three of the survey of the said Choctaw cession intersects the same; thence with said range line, to the line between townships 24 and 25 aforesaid, and thence with the said township line to the beginning.
Port Royal was once the county seat of Coahoma County. It was a rival of Friars Point, five miles up the Mississippi River. In the early days the county seats of the Mississippi River counties were always located on the banks of that stream. When Port Royal was cut off from the river in 1848, its fate was sealed and the county seat of justice was located at Friars Point, which still remained a river town. The latter place had a population of about 1,000 (census of 1920), and received its name in honor of Robert Friar, one of its earliest settlers. Clarksdale, one of the county seats, is now the largest and most important city in the county, and had a population of 7,500 in 1920. Clarksdale was named for John Clark, a brother-in-law of Governor James L. Alcorn, whose home, Eagle’s Nest, was in this county.