Clayton is a town in northern Concordia Parish, Louisiana, United States. The population was 711 at the 2010 census. Cotton is a principal commodity in the area. Clayton is located on the Tensas River, important for fishing and boating, promoted through a U.S. Army Corps of Engineers-maintained boat launch. The Tensas River merges with the Black River in Jonesville in Catahoula Parish.
Among the businesses in the community are Cross Keys Bank and David's Grocery.
A major employer in the town was Clayton Gin Company which closed in the early 2000s and was mostly demolished in the early 2010s. The Clayton Gin was originally constructed in the 1940s by W. Howard Davis and his brother Doyle E. Davis. The gin operated under the name "Davis Bros. Gin Co.". The last surviving brother, Howard Davis, died in 1972 and the gin continued to operate under the management of his son-in-law Sam D. Cole until his death in 1979. The gin was sold in the early 1980s and continued operation as the "Clayton Gin Company" until the early 2000s.