Twelve electoral area directors and four municipal directors govern the affairs of the Cariboo Regional District. The electoral area directors are elected by area voters, and municipal directors are appointed by their municipal council. All directors serve for a four year term.
The Cariboo Regional District provides region-wide library services, recreational facilities, and local fire protection.
The Cariboo District and 100 Mile House are featured prominently in Al Purdy's poem "The Cariboo Horses" to examine the tradition of equinity against human civilization.