Brignall is a village in the Pennines of England, situated close to Barnard Castle. It was historically located in the North Riding of Yorkshire but along with the rest of the former Startforth Rural District it was transferred to County Durham for administrative and ceremonial purposes on 1 April 1974, under the provisions of the Local Government Act 1972.
Brignall sits adjacent to the River Greta, a site of special scientific interest. The River Greta and the Brignall area were painted by John Sell Cotman and J. M. W. Turner amongst others. Bird watching, walking and other outdoor activities can be pursued in the area.
Historically, Brignall was an ecclesiastical parish in the Gilling West Wapentake.