The civil parish is formed by the village of Brandesburton and the hamlets of Burshill and Hempholme. According to the 2011 UK census, Brandesburton parish had a population of 1,522, an increase on the 2001 UK census figure of 1,348.
St Mary's Church, which is surrounded by its churchyard in the north-east corner of the village, is a large, medieval building, with tower, nave, aisles and chancel. It was largely built out of cobbles, but has an early brick clerestory and later south porch. Exhibiting some fragments of Norman work (including a priest's door), it principally dates from the 13th to the 15th centuries, and was restored in 1892. Inside are two noteworthy brasses: on the south side of the chancel the fragments of a (rare) bracket-brass, and on the north side more substantial, full-size brasses to John St Quintin, a former Lord of the Manor, and his wife. The church has been designated a Grade I listed building.
On the village green is a Grade II listed market cross.
The village is situated off the A165 which used to pass through the village until the opening of a bypass of it, and neighbouring village Leven, in 1994. A railway station was proposed in 1901 as part of the North Holderness Light Railway between Beverley and North Frodingham, but the line was never built.
From the 1930s and into the Second World War RAF Catfoss was located just to the north-east of the village.