The remains of a Roman farmhouse were found during an excavation of the Common in 1955, as well as later Saxon remains. These were not considered to be worth retaining in an exposed condition and so the area was re-covered.
Bix Brand's original parish church of Saint James is a small Norman building in Bix Bottom, about north of the village. It has a nave, chancel and several Norman lancet windows. Later additions include the Perpendicular Gothic east window and another Perpendicular window in the south wall. In 1874 the architect John Gibson completed the village's new Church of England parish church, closer to the centre of the village, also dedicated to Saint James. The new church has a north aisle and transept as well as a nave and chancel. Two of the north aisle windows contain sections of late 15th century Flemish stained glass.The old church was abandoned in 1875. It is now ruined and overgrown, and scenes from the 1971 Tigon British Film Productions film Blood on Satan's Claw were filmed there.
Bix Manor has a 17th-century barn.
The main road between Henley and Wallingford passes through the parish. It was made into a turnpike in 1736 and ceased to be a turnpike in 1873. The hill between Fair Mile, on the edge of Henley, and Bix was made a dual carriageway in 1937, one of the earliest dual carriageways in the country. It is now the A4130 road.