Barthomley is a village and ancient parish, and is now a civil parish in the unitary authority of Cheshire East and the ceremonial county of Cheshire, England. According to the 2001 census the parish had a population of 202. The village is situated near junction 16 of the M6 motorway and by the border with Staffordshire. It is about three miles south-west of Alsager.
The hamlet of Radway Green, location of a Royal Ordnance Factory, is within the parish, north-east of the village of Barthomley and just outside Alsager. There was a railway station in Radway Green, on the Crewe to Derby Line, as well as a station reserved for the factory at Millway. However, both of these are now closed. Radway Green and Barthomley station closed to goods traffic on 7 June 1964, followed by its closure to passengers on 7 November 1966.