Amotherby is a village and civil parish in the Ryedale district of North Yorkshire, England. It is about 3 miles west of Malton. The village appears in the Domesday Book as 'Aimundrebi' which is derived from 'Eymund's farm'.
The 2001 census recorded a population of 357 for the parish. There is a church dedicated to St Helen.
Amotherby sits on two main roads, the B1257 between Helmsley and Malton and the Kirkbymoorside to Malton road. Both roads meet at a busy junction in the village, with traffic from Helmsley and Kirkbymoorside meeting towards Malton.
Prior to the nationwide municipal reorganization of 1974, Amotherby was located in Malton Rural District. Historically, it was located in the ecclesiastical parish of Appleton-le-Street in the Rydale Wapentake.