|timezone =CST |utc_offset = −6 |timezone_DST = CDT |utc_offset_DST = −5 |latd=29|latm=19|lats=27|latNS=N |longd=100|longm=55|longs=54|longEW=W |elevation_footnotes = |elevation_m = 271 |elevation_ft = |postal_code_type = ZipCode |postal_code = 26200 - 26328 |area_code = 877 |blank_name = |blank_info = |blank1_name = |blank1_info = |website = http://www.acuna.gob.mx/ |footnotes = }}
and a mean height above sea level of 271 meters. It stands on the Rio Grande (locally known as the Río Bravo), which at this point marks the U.S.-Mexico border, and offers two border crossings via Lake Amistad Dam International Crossing and Del Río-Ciudad Acuña International Bridge with the neighbouring city of Del Rio in the U.S. state of Texas. It serves as the municipal seat of the surrounding municipality of Acuña. In the 2010 census the city had a population of 134,233 whereas the municipality's population was 136,755. The city is the fifth-largest community in the state and the fastest growing city in Mexico. The area is served by the Ciudad Acuña International Airport.
The Del Rio-Ciudad Acuña Metropolitan Area (DR-CA) is the seventh largest bi-national metropolitan area along the United States-Mexican border. The city of Del Rio is situated in the U.S. state of Texas on the north side of the Rio Grande and Ciudad Acuña is located in the Mexican state of Coahuila south of the river. This metropolitan area is also known as "Tierra de la Amistad".
The Del Rio Micropolitan Area's population was 50,000 people in 2007, and the Ciudad Acuña Metropolitan Area's population was 220,000 people in 2008. The 2008 population of Greater Del Rio-Ciudad Acuña Metropolitan Area is 270,000.