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Lucrezia de' Medici (14 February 1545 – 21 April 1561) was the daughter of Cosimo I de' Medici, Grand Duke of Tuscany, and Eleanor of Toledo. Born in Florence, she was the first wife of Alfonso II d'Este, Duke of Modena and Ferrara, whom she married on 3 July 1558. She did not move to Ferrara until February 1560, for her husband Alfonso d’Este was fighting in France. Lucrezia died in 1561, probably from tuberculosis. For about a month her symptoms had been fever, severe weight loss, constant coughing and a permanently bleeding nose.
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