Facts and Events
Isabella (1400 – 28 February 1453) was suo jure Duchess of Lorraine, from 25 January 1431 to her death in 1453. She was the first wife of Duke René of Anjou, King of Naples, and the mother of his children, which included Margaret of Anjou, Queen consort of England as the wife of Henry VI.
From 1435 to 1442, Isabella was Queen consort of Naples, and from 1442 until her death she was the titular queen consort. During her husband's absences, she acted as regent for his domains.