Facts and Events
In 1509 he married Margaret of Angoulême, sister to Francis, Duke of Valois, who would in 1515 become King Francis I of France. Their marriage was childless: his wife was allowed to retain most of his titles.
As first prince of the blood, Charles was a prominent figure in the early part of his brother-in-law's reign. He fought at Marignano in 1515, and in 1521 defended Champagne against an imperial invasion. He accompanied his brother-in-law on his second expedition to Italy in 1525, and after the disaster at Pavia, took command of the defeated French forces, leading them in retreat back to French territory. He was made a scapegoat for the defeat and accused of abandoning the king, and died soon after. Although Charles had a sister, Françoise, who survived him, his widow took possession of his lands after his death.