There are at least two Houston family line of in Southwest Virginia prior to the end of the Period of Indian Hostilities.
Mill Creek Hundred Houston'sAbout 1772 Person:William Houston (21) established Houston's Fort in the Moccassin Creek watershed. Person:John Walker (149), son of Ann Houston and John Walker, settled adjacent to William, and it is assumed that Ann was closely related to him. Ann has been shown to be the daughter of a Person:Christopher Huston (1) who died on Mill Creek Hundred in Delaware in 1726. Christopher identified two sons in his will, William and Robert. He is believed by some to have had a third son, James who lived on the Brandywine Creek, but predeceased his father. Son Samuel died without issue, so William is thought to be either a son or possibly a grandson of either James, William or Robert, making him a nephew of Ann Houston.
General Sam Houston Lineage There were several other Houstons in the general area, at least some of whom are believed to be in the GSH lineage, and unrelated to the MCH lineage.